The modern city is the focus and the result of the urbanizational process, which leaves the mark on the development of an existing social model. If one explores the city as an element of a society, then it appears as a socio-spatial form of its existence. A high level of the centralization and a strong powerful vertical with weak horizontal links, including between regions and cities, leads to a distorted vision of the position of one or another region or a big city in the economy of the state, in the social, cultural sphere and in the politics. Large cities with large areas and number of population at a certain stage of their development face the invocation of spatial problems caused by various objective factors and conditions that are inherent in one or another territory. The bigger the area of the city, the more irregularly the potential of the population, of material and cultural resources is located on its territory, the more acute the problems of spatial disproportions are, which may under certain conditions pose a threat to the further development and the prosperity. Taking into account a many-year disregard of the importance of the state regional policy concerning the development of large cities, a reduction of its size, a suspention of the construction in it, a crisis in management, an ignoring of the effect and consequences caused by various instruments and measures of sectoral policies on the citys space, an accessibility of its territories, a building activity, an attractiveness for life and running business, their competitiveness and investment attractiveness, their stability and security, their tourism potential and social prosperity, it is proposed to study the development of space, the efficiency of its use and the degree of importance of increasing the prosperity of large cities as the commanders of states of our country. Afterwards, today, in the context of growing the global civilizational inquiries, the changes in the role and the position of individual cities in a world system of economic and political coordinate systems, the question of production a new effective state regional policy, especially the regulation of the development of large cities and the effective use of their spatial potentials in Ukraine, is becoming extremely relevant.