The aviation industry is undoubtedly the most important part of transportation activities. The air transport sector has a great importance in the global market both in terms of transportation and in terms of economy. It is inevitable that this sector, which is constantly developing and raising its standards, will be affected by natural situations that may occur. The aviation sector, which can be easily affected by possible crises due to its fragile structure, has recently been adversely affected by the September 11 Attacks, Gulf Wars, SARS Virus, 2008 Global Crisis and Covid-19 pandemic. In this study, Covid-19 was discussed as the latest crisis experienced by the aviation industry, and it was aimed to examine the effects of the epidemic and pandemic on the industry. The safety performances of the airlines operating in the global airspace within the scope of the Covid-19 epidemic and pandemic were analyzed by MCDM methods, and the preference ranking of the relevant airline companies was created based on the results of this analysis. As a result of the analyzes made, the company with the highest degree of preferability was seen as Singapore Airlines, while the operator with the lowest rating was Pegasus.