This article responds to calls for pragmatic context-driven scholarship and administration in regard to the strategic use of successful change management models in the corporate business environment. Specifically, this paper attempts to reconcile the disconnect between the need for change in global organizations and the ability to leverage effective change management approaches productively to obtain the desired results. The purpose of this paper is to evaluate what may have gone wrong with change management and explore an alternative approach to managing global change that is designed to bring a progressive, effective method to change across diverse organizations within a single, integrated methodology. Where today a singular approach is most commonly used in attempts to facilitate change to derive business goals and objectives, this comparative analysis presents a unified approach rooted in three well-known change models, while adding a new component – neuroscience – to the framework. The objective is to achieve sustainable, effective change management practices in global organizations with an appreciation for leveraging change as a means to better understanding and leveraging diverse people to create unique components of competitive advantage. This paper may offer a substantial contribution to the field of Change Management through the development of a theoretically sound approach to evolving the methodology to encompass a multidisciplinary approach to implementing change in organizations.