Motor vehicle accidents have adverse socioeconomic and health effects on people at the national, community and individual levels in South Africa. This article unpacks the contributory factors to road traffic crashes in the City of Tshwane municipality, South Africa. A mixed-method approach was adopted for the study. Findings from the study (amongst others) pointed to both the involvement and significance of human, road, law enforcement and vehicle factors as key contributors to road traffic crashes. The study makes recommendations from the research findings.