Alienation, one of the inevitable manifestations of modern life, refers to the individual's loss of relationship with her/his family and friends, society and ultimately her/his own existence. The phenomena of industrialization, capitalism and urbanization have created individuals who work constantly and break away from society. Alienation, which causes people to experience problems with themselves and their social environment, has a transformative effect on society. As a result of this effect, the number of lonely, unhappy, depressed and exhausted people in society is increasing day by day. It is inevitable that individuals who are deprived of human relations and communication opportunities will quickly become alienated from their environment. The concept of alienation is one of the dominant themes in Turkish literature from the 1950s until today. Mevsim Yenice, one of the young story writers of contemporary Turkish literature, also focuses on the concept of alienation in her story book titled Tekme Tokatlı Şehir Rehberi. In the stories in the book, individuals who are alienated from family, society and gradually their own existence, and the dilemmas of these individuals are discussed in a humorous style. Yenice's story characters are incompatible and asocial people who are in conflict with the society they live in and their family members. Some of the tragic and traumatic events they experienced in the stories led the characters to be excluded by society, to become lonely, and to become increasingly alienated from their immediate or distant environments. In various stories, it is seen that the situation of alienation is sometimes directed towards the family circle and sometimes towards the society on a larger scale. In the stories, the psychological reflections of alienation appear in the form of suicide, pleasure from being beaten, and numbness. The story characters, who are at the forefront with their loneliness, failures and unhappiness, try to stay strong and hold on to life despite all these negativities. This paper aims to read the characters in Mevsim Yenice's story book titled Tekme Tokatlı Şehir Rehberi through the concept of alienation.